C3orf80


Membrane protein C3orf80 is a human protein encoded by the C3orf80 gene.

Gene

C3orf80 is on chromosome 3 from 160,225,422 to 160,228,213 bp. It spans 2,792 bases on the plus strand and contains only one exon.
Neighboring genes of C3orf80 include IFT80, BRD7P2, and SMC4.
GeneOrientationLocationFunction
IFT80Minus strand160,256,986-160,399,880Part of IFT complex B
BRD7P2Plus strand160,100,691-160,102,912Pseudogene of BRD7
SMC4Plus strand160,399,274-160,434,954Part of the condensin complex

Transcript

The mRNA transcript of human C3orf80 contains no introns, has only one isoform, and the complete sequence has been found.

Expression

Expression of C3orf80 is highest in the cerebral cortex, esophagus, and colon. A higher expression of C3orf80 has been observed from multiple sclerosis brain lesions. Expression of C3orf80 has also been found by machine learning to be associated with different forms of cancer. A two-fold increase in expression was found in low-grade glioma based on whether the cells expressed CMTM3 or not. A 107.61 fold increase in expression was seen after inhibition of CLIC1 in esophageal squamous cell carcinoma. C3orf80 was one of three genes' expression levels found to form the best machine learning model for predicting invasive carcinoma. Finally, C3orf80 was one of 34 genes used in a machine learning model to predict if patients had a response to FOLFIRI chemotherapy.

Protein

C3orf80 is 247 amino acids long, has a molecular weight of 25.6 kDa before modifications, and has been proven to exist at the protein level, however, the tertiary structure is unknown. The protein is annotated to be a single-pass membrane protein, localizing at the cell membrane. The amino acid sequence of C3orf80 contains a signal peptide, transmembrane region, disordered region, glycosylation, and domain of unknown function 4719.
Within humans, there is 0.02 ppm of C3orf80, a relatively low amount compared to other proteins. Immunochemical staining has shown protein localization in cilia of glandular cells of the human fallopian tube.

Evolution

Orthologs

Orthologs of human C3orf80 are specific to vertebrates. The farthest ortholog of human C3orf80 is found in Callorhinchus milii, with a date of divergence of 462 million years ago. Orthologs can be found in all major groups from Chondrichthyes to Mammalia; however, Aves have unique orthologs of C3orf80 compared to any other group.
Scientific NameCommon NameGroupDate of Divergence Ortholog Accession NumberSequence LengthSequence IdentitySequence Similarity
Homo sapiensHumanMammalia0NP_001161686.1247100%100%
Mus musculusHouse mouseMammalia87NP_001161468.124792%94%
Antechinus flavipesYellow-footed antechinusMarsupialia160XP_051839055.123759%65%
Sarcophilus harrisiiTasmanian devilMarsupialia160XP_031813452.123958%65%
Alligator mississippiensisAmerican alligatorReptilia319XP_019347204.121054%58%
Mauremys muticaYellow pond turtleReptilia319XP_044885017.120350%54%
Prinia subflavaTawny-flanked priniaAves319XP_063264524.117927%33%
Gallus gallusRed junglefowlAves319XP_025009399.214526%31%
Aquila chrysaetosGolden eagleAves319XP_029884193.131920%25%
Pseudophryne corroboreeSouthern corroboree frogAmphibia352XP_063772225.119448%54%
Bufo bufoCommon toadAmphibia352XP_040286993.118946%53%
Pleurodeles waltlIberian ribbed newtAmphibia352KAJ1088024.124041%47%
Rhinatrema bivittatumRhinatremaAmphibia352XP_029473235.120641%46%
Protopterus annectensWest African lungfishSarcopterygii408XP_043926856.121038%44%
Latimeria chalumnaeWest Indian Ocean coelacanthSarcopterygii415XP_006002129.118939%44%
Polypterus senegalusGray bichirActinopterygii429XP_039612526.119634%45%
Chelmon rostratusCopperband butterflyfishActinopterygii429XP_041796725.121931%42%
Danio rerioZebrafishActinopterygii429XP_068069764.116231%39%
Stegostoma tigrinumZebra sharkChondrichthyes462XP_048398267.119630%40%
Callorhinchus miliiAustralian ghostsharkChondrichthyes462XP_007888000.122029%35%