Brendan O'Brien

• Brendan O'Brien (bishop), Roman Catholic archbishop of Kingston, Ontario, Canada
• Brendan O'Brien (cricketer), Irish former cricketer
• Brendan O'Brien (journalist), senior Irish journalist on RTÉ's Prime Time current affairs programme
• Brendan O'Brien (record producer), record producer, mixer, engineer, and musician
• Brendan O'Brien (screenwriter), American screenwriter
• Brendan O'Brien (voice actor), actor and voice of many Crash Bandicoot characters