Beatrice (drug)

Beatrice, also known as 4-methyl-2,5-dimethoxy-N-methylamphetamine or as N-methyl-DOM, MDOM, or MDO-D, is a psychoactive drug of the phenethylamine, amphetamine, and DOx families. It is a substituted methamphetamine and a homologue of 2,5-dimethoxy-4-methylamphetamine.

Use and effects

In Alexander Shulgin's book PiHKAL, the minimum dose is listed as 30mg, and the duration is listed as 6 to 10hours. Beatrice produces a vague feeling of openness and receptiveness, and causes a stimulative effect. It also causes diarrhea. The drug is one of Shulgin's "ten classic ladies", a series of methylated DOM derivatives.

Pharmacology

Pharmacodynamics

Beatrice shows affinity for serotonin receptors. Its affinities were 415nM for the 5-HT₂ receptor and 3,870nM for the 5-HT₁ receptor. The affinity of Beatrice for the serotonin 5-HT₂ receptor was about 4-fold lower than that of DOM. Functional activities were not reported.
Beatrice substituted for DOM in rodent drug discrimination tests, albeit with relatively low potency.

Chemistry

Synthesis

The chemical synthesis of Beatrice has been described.

Analogues

Analogues of Beatrice include N-methyl-DOET, N-methyl-DOI, N-methyl-DOB, and IDNNA. N-Methyl-DOI is a potent agonist of the serotonin 5-HT_2A receptor similarly to DOI, but with several-fold reduced potency and slightly reduced efficacy.

History

Beatrice was first described in the scientific literature by Beng T. Ho and colleagues in 1970. Subsequently, it was described in greater detail by Alexander Shulgin in his 1991 book PiHKAL.

Society and culture

Legal status

Canada

Beatrice is a controlled substance in Canada under phenethylamine blanket-ban language.

United States

In the United States, Beatrice is a Schedule I isomer of DOET.