| Name | Animal | Publisher | Description | |
| Ace the Bat-Hound | Dog | DC Comics | The pet dog and sidekick of Batman. | |
| Beasts of Burden | Dogs | Dark Horse Comics | A dog superhero team. | |
| Beppo | Monkey | DC Comics | A super-monkey from the planet Krypton. | |
| Captain Carrot | Rabbit | DC Comics | A rabbit that can gain powers similar to those of Superman. | |
| Ch'p | Squirrel | DC Comics | A squirrel-like alien and a member of the Green Lantern Corps. | |
| Comet | Horse | DC Comics | A sapient horse that was once an ancient Greek centaur. | |
| Cosmo the Spacedog | Dog | Marvel Comics | A telepathic Soviet space dog. | |
| Cutey Bunny | Rabbit | Joshua Quagmire | An anthropomorphic rabbit superheroine named Kelly O'Hare. | |
| Congorilla | Gorilla | DC Comics | A human that transformed into a super-powered gorilla. | |
| Detective Chimp | Chimpanzee | DC Comics | A highly intelligent chimpanzee detective. | |
| Devil Dinosaur | Dinosaur | Marvel Comics | A giant red theropod dinosaur. | |
| Dinkan | Mouse | Mangalam Publications | A superhero mouse from Kerala, India | |
| Dogpool | Dog | Marvel Comics | An alternate-universe version of Deadpool. | |
| Donatello | Turtle | Mirage Studios | One of the main characters of the Teenage Mutant Ninja Turtles franchise. | |
| Entoman | Duck | David Füleki | A vulgar, misanthropic German duck superhero. | |
| Gorilla-Man | Gorilla | Marvel Comics | A superhero gorilla. | |
| Hellcow | Cow | Marvel Comics | A cow that was bitten by Dracula, turning her into a vampiric superhero. | |
| Hit-Monkey | Japanese macaque | Marvel Comics | A Japanese monkey that works as an assassin. | |
| Hoppy the Marvel Bunny | Rabbit | Fawcett Comics | A rabbit with the powers of Captain Marvel. | |
| Howard the Duck | Duck | Marvel Comics | An anthropomorphic duck often appearing in satirical or humorous comics. | |
| Jeff the Land Shark | Land shark | Marvel Comics | The pet and sidekick of Gwenpool, Hawkeye, and Deadpool. | |
| Jennika | Turtle | IDW Publishing | A character from the Teenage Mutant Ninja Turtles franchise. | |
| Krypto | Dog | DC Comics | The pet dog and sidekick of Superman. | |
| Leonardo | Turtle | Mirage Studios | One of the main characters of the Teenage Mutant Ninja Turtles franchise. | |
| Lockheed | Dragon | Marvel Comics | The alien dragon companion of Kitty Pryde. | |
| Lockjaw | Dog | Marvel Comics | An Inhuman bulldog with teleportation powers. | |
| Michaelangelo | Turtle | Mirage Studios | One of the main characters of the Teenage Mutant Ninja Turtles franchise. | |
| Miyamoto Usagi | Rabbit | Dark Horse Comics | A rabbit rōnin. | |
| Old Lace | Dinosaur | Marvel Comics | A genetically-engineered Deinonychus and partner of Gertrude Yorkes. | |
| Paperinik | Duck | Arnoldo Mondadori Editore | The superhero alter ego of Donald Duck. | |
| Raphael | Turtle | Mirage Studios | One of the main characters of the Teenage Mutant Ninja Turtles franchise. | |
| Rex the Wonder Dog | Dog | DC Comics | A superhero White Shepherd dog with various superpowers. | |
| Rocket Raccoon | Raccoon | Marvel Comics | A superhero that is a member of the Guardians of the Galaxy. | |
| Solovar | Gorilla | DC Comics | A gorilla supporting character of the Flash. | |
| Spider-Ham | Pig | Marvel Comics | An alternate-universe version of Spider-Man. | |
| Streaky the Supercat | Cat | DC Comics | The pet cat of Supergirl. | |
| Super Duck | Duck | Archie Comics | A comedic superhero duck. | |
| Super Rabbit | Rabbit | Timely Comics | A rabbit with a magic ring that grants him invulnerability. | |
| Super-Turtle | Turtle | DC Comics | A superhero turtle inspired by Superman. | |
| Tawky Tawny | Tiger | Fawcett Comics | An anthropomorphic tiger and supporting character of Captain Marvel. | |
| Terrific Whatzit | Turtle | DC Comics | A turtle with powers similar to those of the Flash. | |
| Thunderbunny | Rabbit | Charlton Comics | A boy named Bobby Caswell that can transform into a superhero bunny. | |
| Topo | Octopus | DC Comics | The octopus sidekick of Aquaman. | |
| Zabu | Smilodon | Marvel Comics | A saber-toothed cat from the Savage Land and the partner of Ka-Zar. | |