In 2003, Angelo Barrile started working as an assistant doctor in the chirurgical clinic of the Muri hospital. From 2004 to 2005, he was an assistant doctor in the medical clinic in the Bülach hospital. From 2006 to 2009, he was an assistant doctor in the psychiatric hospital of the University of Zürich and from 2009 to 2012 an assistant doctor in the psychiatric-psychological service of the city of Zurich. Since 2012, he has been a doctor in a group practice for general internal medicine in Zurich.