Andy O'Brien
Andy or Andrew O'Brien may refer to:
- Andy O'Brien (footballer), Irish footballer
- Andy O'Brien (hurler), Irish hurler
- Andy O'Brien (journalist), Canadian sports journalist
- Andy O'Brien (politician), Irish Fine Gael senator
- Andrew O'Brien (politician), US Department of State official
- Andrew O'Brien (rugby), New Zealand rugby footballer
Fictional
- Andy O'Brien (EastEnders), a character in ''EastEnders''