1980–81 Alpha Ethniki
The 1980–81 Alpha Ethniki was the 45th season of the highest football league of Greece. The season began on 7 September 1980 and ended on 14 June 1981. Olympiacos won their second consecutive and 22nd Greek title.
The point system was: Win: 2 points - Draw: 1 point.
Teams
| Promoted from 1979–80 Beta Ethniki | Relegated from 1979–80 Alpha Ethniki |
| Atromitos Panserraikos | Iraklis Rodos |
League table
Top scorers
| Rank | Player | Club | Goals |
| 1 |  AttendancesOlympiacos drew the highest average home attendance in the 1980–81 Alpha Ethniki. |