Α-Mannosidaseα-Mannosidase is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.IsoenzymesHumans express the following three α-mannosidase isoenzymes:ApplicationsIt can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.PathologyA deficiency can lead to α-mannosidosis.