Allen Debus attended the Evanstonpublic school system where he showed an early interest in history. A great aunt passed on her legacy of an epoch of music to him in the form of a 1908 Victrola and a record collection up to 1923. Due to the topical material and dialect songs, he wrote "studying this music gave me an opportunity early on to place past events in their historical context". In the contextual approach to history, developments should be compared across fields, and this is a feature of the school of Alexandre Koyre, I. Bernard Cohen, and Walter Pagel, the latter two being teachers of Debus.
Higher education
Debus studied chemical engineering and history, graduating with a major in chemistryin the summer of 1947 from Northwestern University. He pursued his master's degree at Indiana University Bloomington where he had followed John J. Murray. In June 1949 he presented his master's thesisRobert Boyle and Chemistry in England 1660-1700 under John J. Murray. Subsequently, he worked towards a master's in chemistry at the same institution. He went to work for Abbott Laboratories, a company for which he filed five patents. He wrote that slow reaction times for some of his work provided reading time for broader investigations in history of science and chemistry literature. In fall 1956 he began his Ph.D. studies at Harvard University under I. Bernard Cohen. His teaching assistant work was supervised by Leonard K. Nash. In a seminar with W. K. Jordan he presented a paper on the English followers of Paracelsus which received the Bowdoin Prize in the Natural Sciences, the first of two from his years at Harvard. In September 1959 he went to London, England to delve more deeply into the topic. There he met regularly with Walter Pagel and attended University College of London courses given by Douglas McKie. Returning to Harvard, he completed the requirements for a Harvard Ph.D. in history of science.
Professor
In 1961, Debus took up a position at the University of Chicago under William McNeill in the Department of History, with one-third of the time as assistant professor in history of science, and two-thirds in undergraduate physical science coursework. In 1965 he was raised to Associate Professor on the strength of his book The English Paracelsians. For the school-year 1966/7 he went on an overseas fellowship to Churchill College, Cambridge. Back at the University of Chicago, Debus described attempts by the philosophy department to intrude on the history of science program in the history department. Debus was instrumental in the development of the Morris Fishbein Center: he served as its first director for two three-year terms. In 1978 he was elected to the academic chair at University of Chicago established in honor of Morris Fishbein. Allen G. Debus developed a three-quarter sequence in history of science, leading from ancient science to the beginning of the twentieth century. He also led seminars in Renaissance science and medicine. He was at the Institute for Advanced Study in Princeton working on the Renaissance chemical philosophy. He was awarded the George Sarton Medal and the Pfizer Award from the History of Science Society. He was also awarded the Dexter Award of the American Chemical Society and the Edward Kremers Award of the American Institute of the History of Pharmacy. In 1984 he received an honorary Ph.D. from the Catholic University of Louvain.
Family
Allen G. Debus noted that his academic career was an innovation in his familial lineage. His father formed the company Modern Boxes, where Allen served as salesman for a time in 1950. Allen met Brunilda Lopez Rodriguez from Puerto Rico at Indiana University. They married in 1951, and studied Latin, French, and German together preparing for Debus' push for the Ph.D. They had three children: Allen, Richard, and Karl.