Aleph-4

Aleph-4, or ALEPH-4, also known as 4-isopropylthio-2,5-dimethoxyamphetamine, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families. It is one of the Aleph series of compounds. In his book PiHKAL, Alexander Shulgin lists Aleph-4's dose as 7 to 12mg orally and its duration as 12 to 20hours. The effects of Aleph-4 have been reported to include closed-eye imagery, enhanced visual appreciation, emotional changes, and physical side effects and toxicity indications, among others. One of the reports remarked that it was "one of the most profound and deep learning experiences" they had had. However, Shulgin was unwilling to push the dose higher than 12mg due to toxicity concerns. The chemical synthesis of Aleph-4 has been described. Aleph-4 was first described in the scientific literature by Shulgin, David E. Nichols, Peyton Jacob III, and other colleagues in 1978. Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991. The drug was encountered as a novel designer drug in Japan in 2009. It is a Schedule I controlled substance in the United States as an isomer of 2C-T-7. The drug is also a controlled substance in Canada under phenethylamine blanket-ban language.