Adaptive Capacity of a DNA Polymerase Clamp-loader ATPase Complex
Adaptive Capacity of a DNA Polymerase Clamp-loader ATPase Complex is a scholarly work, published in 2024 in ''Molecular Biology and Evolution''. The main subjects of the publication include mutagenesis, deoxyribonucleic acid, mutation, genetics, biophysics, clamp, DNA polymerase processivity factor complex, CRISPR, biology, evolutionary dynamics, loader, DNA polymerase, and DNA nanotechnology. Deep mutagenesis shows that the reduced fitness of the chimeric clamp loader is also compensated for by lysine and arginine substitutions of several DNA-proximal residues in the clamp loader or the sliding clamp.