Acquired hemolytic anemia
Acquired hemolytic anemia can be divided into immune and non-immune mediated forms of hemolytic anemia.
Classification
Immune
- Autoimmune hemolytic anemia
- * Warm antibody autoimmune hemolytic anemia
- ** Idiopathic
- ** Linked with primary immunodeficiency/immunodysregulation syndrome.
- ** Lymphoma or chronic lymphocytic leukemia associated.
- ** Secondary to other malignancies.
- ** Associated with SLE or other collagen-vascular disorders.
- ** Secondary to viral infection.
- * Cold antibody autoimmune hemolytic anemia
- * Paroxysmal cold hemoglobinuria
- * Drug-induced autoimmune hemolytic anemia
- Alloimmune hemolytic anemia
- * Hemolytic disease of the newborn
- ** Rh disease
- ** ABO hemolytic disease of the newborn
- ** Anti-Kell hemolytic disease of the newborn
- ** Rhesus c hemolytic disease of the newborn
- ** Rhesus E hemolytic disease of the newborn
- ** Other blood group incompatibility
- * Alloimmune hemolytic blood transfusion reactions
Non-immune
- Traumatic hemolytic anemia
- * Impact
- * Macrovascular defects-prostheses
- * Microvascular causes
- ** Disseminated intravascular hemolysis
- ** Thrombotic thrombocytopenic purpura
- ** Typical and atypical hemolytic uremic syndrome
- ** Other microvascular abnormalities
- * Hypersplenism
- * Hemolytic anemia due to toxic effects on the membrane
- ** Spur cell anemia
- ** External toxins
- *** Animal or spider bites
- *** Metals
- *** Organic compounds
- ** Infectious agents
- Paroxysmal nocturnal hemoglobinuria