A comprehensive analysis of precursor microRNA cleavage by human Dicer
A comprehensive analysis of precursor microRNA cleavage by human Dicer is a scholarly work, published in 2012 in ''RNA''. The main subjects of the publication include cleavage, biology, DNA nanotechnology, small interfering RNA, ribonucleic acid, microRNA, Dicer 1, ribonuclease III, genetics, RNA interference, RNA silencing, cell biology, Ribonuclease III, RNA analysis, nuclease, molecular biology, and Argonaute protein family. By large-scale in vitro dicing assays and mutagenesis studies, authors showed that human Dicer cleaves most, although not all, of the 161 tested human pre-miRNAs efficiently.