AFC
- AAFC (disambiguation)
- AFC Ajax
- AFC Energy
- AFC Enterprises
- Aberdeen F.C.
- Abstraction-Filtration-Comparison test
- Action for Children
- Adelaide Football Club
- Africa Finance Corporation
- Agenda for Change
- Aggression Fighting Championship
- Agila F.C.
- Air Force Cross (United Kingdom)
- Air Force Cross (United States)
- Airdrieonians F.C.
- Aizawl FC
- Alabama Forestry Commission
- Alkaline fuel cell
- Altitude FC (Canada)
- Altrincham F.C.
- Ambassadors F.C.
- America First Committee
- American Football Conference
- Amsterdamsche FC
- América Football Club (disambiguation)
- Antral follicle count
- Application Foundation Classes
- Aquinas F.C.
- Ards F.C.
- Ardstraw F.C.
- Army Foundation College
- Arsenal F.C.
- Asian Football Confederation
- Atlanta Financial Center
- Australian Fighting Championship
- Australian Film Commission
- Australian Flying Corps
- Automated Frequency Coordination
- Automated fare collection
- Automatic frequency control
- Average fixed cost
- Forces of Freedom and Change
- French Society of Cinematographers
- U.S. Army Futures Command