5-MeO-EiPT

5-MeO-EiPT, also known as 5-methoxy-N-ethyl-N-isopropyltryptamine, is a psychedelic drug of the tryptamine family which has been sold online as a designer drug.

Use and effects

5-MeO-EiPT was not included nor mentioned in Alexander Shulgin's book TiHKAL. When subsequently asked about 5-MeO-EiPT, Shulgin said that he never got around to making or exploring it and that its dose, duration, and effects were unknown. In any case, 5-MeO-EiPT has been used as a novel recreational designer drug.

Pharmacology

Pharmacodynamics

5-MeO-EiPT acts as a potent full agonist of the serotonin 5-HT_2A receptor. It also shows high affinity for the serotonin 5-HT_1A receptor and interacts very weakly with the serotonin transporter. The drug produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. However, it produces a rather weak head-twitch response, suggesting that it might have reduced hallucinogenic effects relative to other psychedelic tryptamines or might be non-hallucinogenic. The serotonin 5-HT_1A receptor antagonist WAY-100635 augmented the head-twitch response induced by 5-MeO-EiPT in rodents. The drug also produces hypothermia and hypolocomotion in rodents.

Chemistry

Analogues

Analogues of 5-MeO-EiPT include ethylisopropyltryptamine, 4-HO-EiPT, 4-AcO-EiPT, 5-MeO-DMT, 5-MeO-DET, 5-MeO-DPT, 5-MeO-DiPT, 5-MeO-DALT, 5-MeO-MET, 5-MeO-MPT, 5-MeO-MiPT, 5-MeO-MsBT, 5-MeO-EPT, 5-MeO-PiPT, and 5-MeO-iPALT, among others.

History

5-MeO-EiPT was first described by Alexander Shulgin by 2002.

Society and culture

Legal status

5-MeO-EiPT is illegal in Japan.
5-MeO-EiPT is illegal in Italy.
Sweden's public health agency suggested classifying 5-MeO-EiPT as a hazardous substance, on May 15, 2019.