5-MeO-DPT
5-MeO-DPT, also known as 5-methoxy-N,''N-dipropyltryptamine, as well as O''-methyl-N,''N''-dipropylserotonin, is a psychedelic drug of the tryptamine family related to 5-MeO-DMT. It is taken orally. The drug has been encountered as a novel designer drug.
Use and effects
included 5-MeO-DPT in a subsection in the 5-MeO-DET entry of his book TiHKAL. He did not explicitly provide a dose range or duration for 5-MeO-DPT, but did report having tried it at doses of 4 to 8.4mg orally, with 4mg producing only threshold effects and doses of 6 to 8.4mg being more meaningfully active. In a subsequent literature review however, Shulgin gave an explicitly defined dose range of 6 to 10mg orally. Its onset was described as being 12minutes to within 1hour and its duration was 2 to 4hours.According to Shulgin, 5-MeO-DPT's actions are ambiguous and not totally positive. This led to him tucking discussion of the drug away in the 5-MeO-DET entry of TiHKAL as opposed to giving 5-MeO-DPT its own entry in the book. The effects of 5-MeO-DPT were only vaguely described. The 4mg dose produced only threshold effects described as "something". At the 6mg dose, the effects included possible eroticism, not too much lightheadedness, and comfortableness, with a plus-two rating on the Shulgin Rating Scale. On the other hand, at the 8.4mg dose, there were 5-MeO-DMT-like "head noises" or "bells" described as "bad" and an underlying 5-MeO-DMT-like "turn on" described as "good". However, per Shulgin, while these effects alternated, the unpleasant negative effects overall outweighed the positive and desired effects. There were no apparent cardiovascular effects at this dose. Shulgin stated that he had "better things to do with my time" and did not further explore 5-MeO-DPT or evaluate higher doses.
5-MeO-DPT's lower homologue 5-MeO-DET was found to produce unique and strong side effects such as lightheadedness, dizziness, and vertigo at low doses which precluded it from being tolerated or used at hallucinogenic doses. Shulgin synthesized and tested 5-MeO-DPT in the hopes that the vertigo-related side effects of 5-MeO-DET would be reduced or eliminated while the hallucinogenic and other desired effects such as sexual enhancement would be preserved. However, while 5-MeO-DET-like side effects were not described, Shulgin nonetheless deemed 5-MeO-DPT an unpromising compound.
Interactions
Pharmacology
Pharmacodynamics
5-MeO-DPT is a potent and high-efficacy agonist of the serotonin 5-HT2A and 5-HT1A receptors. Additionally, the drug has been found to act as a weak serotonin reuptake inhibitor and serotonin 5-HT2C receptor agonist with lower potency.The drug fully substitutes for the serotonin 5-HT2 receptor agonist and serotonergic psychedelic DOM in rodent drug discrimination tests and partially substitutes for the serotonin 5-HT1A receptor agonist 8-OH-DPAT in these tests followed by behavioral disruption at higher doses. 5-MeO-DPT also substitutes for 5-MeO-DMT in rodent drug discrimination tests.