8-OH-DPAT
8-OH-DPAT is a serotonin 5-HT1A receptor agonist of the 2-aminotetralin family which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonists to have been discovered.
Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a serotonin 5-HT7 receptor agonist and serotonin reuptake inhibitor or releasing agent as well.
In animal studies, 8-OH-DPAT has been shown to possess antidepressant, anxiolytic, serenic, anorectic, antiemetic, hypothermic, hypotensive, bradycardic, hyperventilative, and analgesic effects.