5-HO-DPT
5-HO-DPT, also known as 5-hydroxy-N,''N-dipropyltryptamine, as well as N'',N-dipropylserotonin, is a serotonin receptor modulator of the tryptamine and 5-hydroxytryptamine families. It is the N,''N''-dipropyl derivative of serotonin.
Pharmacology
Pharmacodynamics
The drug shows affinity for the serotonin 5-HT1A receptor, the serotonin 5-HT1B receptor, and the serotonin 5-HT2 receptor. 5-HO-DPT was not tested itself, but its O-methyl ether 5-MeO-DPT fully substituted for the psychedelic drug DOM in rodent drug discrimination tests and partially substituted for 8-OH-DPAT in these tests followed by behavioral disruption at higher doses.5-Hydroxytryptamines like bufotenin are known to be hydrophilic and peripherally selective, in turn resulting in difficulty crossing the blood–brain barrier and exerting central effects. However, 5-HO-DPT is notable in having much greater lipophilicity in comparison to bufotenin owing to its propyl groups.