5-HO-MET

5-HO-MET, also known as 5-hydroxy-N-methyl-N-ethyltryptamine, is a psychedelic drug of the tryptamine and 5-hydroxytryptamine families related to bufotenin. It is the derivative of bufotenin in which one of the two methyl groups at the amine has been extended to an ethyl group. The drug is also an analogue of methylethyltryptamine, 4-HO-MET, and 5-MeO-MET. 5-HO-MET was reported as a novel designer drug in Canada in 2025. Its predicted log P is 1.6, relative to 1.2 in the case of bufotenin.