5-APBT
5--1-benzothiophene is a monoamine releasing agent and serotonin receptor agonist of the amphetamine and benzothiophene families. It is related to MDA and other MDA bioisosteres like the benzofurans.
The drug acts as a potent serotonin–norepinephrine–dopamine releasing agent and full agonist of the serotonin 5-HT2 receptors. It has approximately 4- and 9-fold preference for induction of serotonin release over norepinephrine and dopamine release, respectively, in rat brain synaptosomes. 5-APBT does not increase locomotor activity in rodents and hence does not appear to have stimulant-like effects. However, it does produce the head-twitch response, a behavioral proxy of psychedelic effects, and hence may have hallucinogenic effects. The drug is a potent monoamine oxidase inhibitor, specifically of monoamine oxidase A .
5-APBT was first described in the scientific literature by 2020.