4-MeO-DiPT


4-MeO-DiPT, also known as 4-methoxy-N,''N-diisopropyltryptamine, is a novel receptor modulator">receptor (biochemistry)">receptor modulator of the tryptamine family related to known psychedelic tryptamines like psilocin and 5-MeO-DMT. It is the 4-methoxy analog of DiPT and the O''-methyl ether of 4-HO-DiPT. Very little data exists about the human use, metabolism, and toxicity of 4-MeO-DiPT.

Use and effects

4-MeO-DiPT is not known to have been assessed in humans. It is unknown whether the drug produces psychedelic effects in humans.

Pharmacology

Pharmacodynamics

4-MeO-DiPT acts as a serotonin reuptake inhibitor and non-selective serotonin receptor agonist, including of the serotonin 5-HT2A, and 5-HT2C receptors. It shows the highest potency as a serotonin reuptake inhibitor with 40- to 50-fold selectivity for the serotonin transporter over the 5-HT2A receptor, moderate potency as an agonist of the 5-HT2C receptor, and low potency with high efficacy as an agonist of the 5-HT1A receptor. Affinities towards receptors outside of the serotonin receptor family have not yet been assessed.
Increased extracellular concentrations of serotonin, resulting from SERT blockade, similarly to 4-MeO-MiPT may compete at 5-HT2A, altering or blunting effects mediated by this receptor. This profile makes 4-MeO-DiPT a potential candidate for elucidating the role of SERT blockade in the mechanisms underlying serotonergic psychedelic action.

Chemistry

4-MeO-DiPT is a synthetic derivative of the substituted tryptamine and 4-methoxytryptamine families. It is the 4-methoxy analogue of N,''N-diisopropyltryptamine and the O''-methyl ether of 4-HO-DiPT.

Analogues

of 4-MeO-DiPT include N,N-diisopropyltryptamine, 4-methoxytryptamine, 4-MeO-MiPT, 4-MeO-DMT, 4-HO-DiPT, 4-AcO-DiPT, 5-MeO-DiPT, 5-MeO-DMT, and psilocin, among others.

History

4-MeO-DiPT was briefly mentioned by Alexander Shulgin in his 1997 book TiHKAL. Subsequently, it was described and studied further in the early 2020s.

Society and culture

Legal status

United States

4-MeO-DiPT is not an explicitly controlled substance in the United States, but may be considered a Schedule I controlled substance in this country as it is a positional isomer of 5-MeO-DiPT.