2C-Bu
2C-Bu, also known as 4-butyl-2,5-dimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and 2C families. It is the 2C analogue of the DOx derivative DOBU.
Use and effects
2C-Bu was not included in Alexander Shulgin's book PiHKAL and its properties and effects in humans are unknown.Pharmacology
Pharmacodynamics
2C-Bu is a potent and high-efficacy serotonin 5-HT2A receptor partial agonist, with an of 3.9 to 29nM and an of 71 to 93%.Chemistry
Analogues
2C-Bu follows 2C-D, 2C-E, and 2C-P in the homologous series of 4-alkylated 2C derivatives. Higher homologues of 2C-Bu including 2C-Am and 2C-Hx are also known and have been characterized.2C-Bu has several notable skeletal isomers, including 2C-iBu, 2C-tBu, and 2C-sBu. 2C-iBu and 2C-tBu are both active and produce hallucinogen-type effects in animals and/or humans. This is in spite of 2C-tBu being predicted to be inactive and DOTB being inactive as a hallucinogen in animals and humans. 2C-iBu may have reduced hallucinogenic potency than other 2C drugs and is being developed as a potential anti-inflammatory medication.