2025–26 AFC Champions League Two knockout stage
The knockout stage of the 2025–26 AFC Champions League Two is scheduled to be played from 10 February to 16 May 2026. A total of 16 teams will compete in the knockout stage.
Qualified teams
The following teams have advanced from the group stage.
| Region | Group | Winners | Runners-up |
| West Region | A | Al Wasl | Esteghlal |
| West Region | B | Al Ahli | Arkadag |
| West Region | C | Al-Hussein | Sepahan |
| West Region | D | Al-Nassr | Al-Zawraa |
| East Region | E | Macarthur FC | Công An Hà Nội |
| East Region | F | Gamba Osaka | Ratchaburi |
| East Region | G | Persib | Bangkok United |
| East Region | H | Tampines Rovers | Pohang Steelers |
Format
In the knockout stage, 16 teams will play a single-elimination tournament, split by Region. Each tie will be played on a home-and-away two-legged basis, except the final which will be played as a single match. Extra time and penalty shoot-out will be used to decide the winners if necessary. The order of matches was determined at the draw, except for the final, which was pre-determined on a rotation basis, with the match to be hosted by the team from the West Region. The draw for the knockout stage was held on 30 December 2025.Schedule
The schedule of the competition is as follows.Bracket
Round of 16
Summary
The first legs will be played between 10 and 12 February, and the second legs between 17 and 19 February 2026.West Region
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East Region
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Quarter-finals
Summary
The first legs will be played between 3 and 5 March, and the second legs between 10 and 12 March 2026.West Region
----East Region
----Semi-finals
Summary
The first legs will be played between 7 and 8 April, and the second legs between 14 and 15 April 2026.Final
The final is scheduled to be played on 17 May 2026. The host of the final was determined by the pre-determined rotation basis, with the team of the West Region hosting the final.