2022 Winston-Salem Open
The 2022 Winston-Salem Open was a men's tennis tournament play on outdoor hard courts. It was the 53rd edition of the Winston-Salem Open, and part of the ATP Tour 250 Series of the 2022 ATP Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 21 through August 27, 2022. It was the last event on the 2022 US Open Series before the 2022 US Open.
Champions
Singles
Adrian Mannarino def. Laslo Đere, 7–6, 6–4Doubles
Matthew Ebden / Jamie Murray def. Hugo Nys / Jan Zieliński, 6–4, 6–2Points & prize money
Prize money
| Event | W | F | SF | QF | Round of 16 | Round of 32 | Round of 48 | Q2 | Q1 |
| Singles | $100,475 | $57,660 | $33,115 | $19,125 | $10,925 | $6,420 | $3,905 | $2,070 | $1,145 |
| Doubles* | $39,530 | $20,700 | $11,690 | $6,780 | $4,000 |
*per team
Singles main-draw entrants
Seeds
† Rankings are as of 15 August 2022.Other entrants
The following players received wildcard entry into the singles main draw:The following players received entry using a protected ranking:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Withdrawals
; Before the tournament- Sebastián Báez → replaced by Márton Fucsovics
- Alexander Bublik → replaced by Adrian Mannarino
- Pablo Carreño Busta → replaced by Taro Daniel
- Hugo Dellien → replaced by Shintaro Mochizuki
- Tomás Martín Etcheverry → replaced by Michail Pervolarakis
- Marcos Giron → replaced by Peter Gojowczyk
- Quentin Halys → replaced by Denis Kudla
- Alex Molčan → replaced by John Millman
- Brandon Nakashima → replaced by Jack Draper
- Oscar Otte → replaced by Richard Gasquet
- Tommy Paul → replaced by Dušan Lajović
- Holger Rune → replaced by Tallon Griekspoor
- Frances Tiafoe → replaced by Steve Johnson
Doubles main-draw entrants
Seeds
† Rankings are as of 15 August 2022.Other entrants
The following pairs received wildcard entry into the doubles main draw :Withdrawals
- Marcelo Arévalo / Jean-Julien Rojer → replaced by Hugo Nys / Jan Zieliński
- Matthew Ebden / Max Purcell → replaced by Matthew Ebden / Jamie Murray
- Santiago González / Andrés Molteni → replaced by Aleksandr Nedovyesov / Aisam-ul-Haq Qureshi
- Wesley Koolhof / Neal Skupski → replaced by Fabrice Martin / Jonny O'Mara
- Kevin Krawietz / Andreas Mies → replaced by Sander Gillé / Joran Vliegen
- Jamie Murray / Bruno Soares → replaced by Nathaniel Lammons / Jackson Withrow