2022 Penrith Panthers season
The 2022 Penrith Panthers season is the 56th season in the club's history. Coached by Ivan Cleary and co-captained by Nathan Cleary and Isaah Yeo, the Panthers competed in the National Rugby League's 2022 Telstra Premiership.
Squad
Player transfers
A † denotes that the transfer occurred during the 2022 season.| Player | Signed from | Until end of | Notes |
| Christian Crichton | Canterbury Bankstown Bulldogs | 2022 | |
| Chris Smith | Canterbury Bankstown Bulldogs | 2022 | |
| Sean O'Sullivan | New Zealand Warriors | 2022 | |
| Soni Luke | 2023 |
| Player | Signed to | Until end of | Notes |
| Tevita Pangai Junior | Canterbury Bankstown Bulldogs | 2024 | |
| Matt Burton | Canterbury Bankstown Bulldogs | 2024 | |
| Brent Naden | Canterbury Bankstown Bulldogs | 2023 | |
| Kurt Capewell | Brisbane Broncos | 2024 | |
| Paul Momirovski | Sydney Roosters | 2024 | |
| Tyrone May | Catalans Dragons | 2022 |
Fixtures
Regular season
- Round 10 attendance refers to the total attendance on day 2 of magic round.
Finals
| Date | Round | Opponent | Venue | Score | Tries | Goals | Attendance | |
| Friday, 9 September | Qualifying Final | Parramatta Eels | BlueBet Stadium | To'o, Edwards, Fisher-Harris | Cleary | 21,863 | ||
| Saturday, 24 September | Preliminary Final | South Sydney Rabbitohs | Accor Stadium | Koroisau, To'o, Leniu, Tago, Cleary | Cleary, Sorensen, Staines | Cleary | 82,415 |