| School | Outgoing coach | Date | Reason | Replacement | Previous position |
| Tuskegee | Reginald Ruffin | June 2, 2022 | Retired | Aaron James | Tuskegee offensive coordinator |
| Morehouse | Rich Freeman | November 9, 2022 | Resigned | Gerard Wilcher | Rice defensive backs |
| Missouri Western | Matt Williamson | November 13, 2022 | Fired | Tyler Fenwick | Southeastern Oklahoma State head coach |
| UNC Pembroke | Shane Richardson | November 13, 2022 | Fired | Mark Hall | Chowan head coach |
| Catawba | Curtis Walker | November 14, 2022 | Resigned | Tyler Haines | Shepherd offensive coordinator and quarterbacks coach |
| Sioux Falls | Jon Anderson | November 14, 2022 | Fired | Jim Glogowski | Minnesota State defensive coordinator |
| Northern Michigan | Kyle Nystrom | November 15, 2022 | Resigned | Shane Richardson | UNC Pembroke head coach |
| Northwestern Oklahoma State | Matt Walter | November 16, 2022 | Resigned | Ronnie Jones | Emerson High School defensive coordinator |
| West Texas A&M | Hunter Hughes | November 21, 2022 | Fired | Josh Lynn | Nebraska–Kearney head coach |
| Texas–Permian Basin | Justin Carrigan | November 28, 2022 | Accepted administrative position | Kris McCullough | East Central head coach |
| Michigan Tech | Steve Olson | November 29, 2022 | Contract expired | Dan Mettlach | Michigan Tech assistant head coach |
| Albany State | Gabe Giardina | November 30, 2022 | Hired by Charleston Southern | Quinn Gray | Alcorn State quarterbacks coach |
| Ashland | Lee Owens | December 2, 2022 | Retired | Doug Geiser | Ashland assistant head coach, offensive line coach, and running game coordinator |
| Minot State | Mike Aldrich | December 2, 2022 | Contract expired | Ian Shields | UNLV offensive assistant |
| Northwood | Leonard Haynes | December 5, 2022 | Became a part of school's faculty | Dustin Beurer | Albion head coach |
| Southeastern Oklahoma State | Tyler Fenwick | December 6, 2022 | Hired by Missouri Western | Bo Atterberry | Southeastern Oklahoma State head coach |
| Wayne State (MI) | Paul Winters | December 9, 2022 | Fired | Tyrone Wheatley | Denver Broncos running backs coach |
| West Florida | Pete Shinnick | December 11, 2022 | Hired by Towson | Kaleb Nobles | Clemson director of offensive player development |
| CSU Pueblo | John Wristen | December 13, 2022 | Retired | Phil Vigil | Western New Mexico head coach |
| Nebraska–Kearney | Josh Lynn | December 13, 2022 | Hired by West Texas A&M | Ryan Held | North Alabama interim head coach |
| Chowan | Mark Hall | December 14, 2022 | Hired by UNC Pembroke | Paul Johnson | Bloomsburg offensive coordinator, wide receivers coach, and tight ends coach |
| Eastern New Mexico | Tye Hiatt | December 21, 2022 | Hired by Southern Utah | Kelley Lee | Veterans Memorial Early College High School head coach |
| East Central | Kris McCullough | December 22, 2022 | Hired by Texas–Permian Basin | John Litrenta | East Central defensive coordinator |
| Western New Mexico | Phil Vigil | December 23, 2022 | Hired by CSU Pueblo | Bill Hickman | Western New Mexico offensive coordinator |
| Southwestern Oklahoma State | Josh Kirkland | January 9, 2023 | Hired by North Texas | Ruzell McCoy | Southwestern Oklahoma State defensive coordinator |
| American International | Kris Kulzer | Before January 11, 2023 | Resigned or fired | Lou Conte | The Citadel offensive coordinator, quarterbacks coach, and fullbacks coach |
| St. Augustine's | David Bowser | January 11, 2023 | Resigned | Howard Feggins | Fayetteville State offensive coordinator |
| Grand Valley State | Matt Mitchell | January 15, 2023 | Hired by Wisconsin | Scott Wooster | Grand Valley State offensive line coach and tight ends coach |
| Mary | Craig Bagnell | February 14, 2023 | Hired by South Dakota | Shann Schillinger | Mississippi State defensive analyst |
| Kentucky State | Paul Hamilton | February 20, 2023 | Full-time coach hired | Felton Huggins | McNeese wide receivers coach |
| Bentley | Alvin Reynolds | April 6, 2023 | Resigned | Saj Thakkar | Harvard running backs coach |
| Colorado Mines | Brandon Moore | April 19, 2023 | Hired by San Diego | Pete Sterbick | Colorado Mines offensive coordinator and quarterbacks coach |
| William Jewell | Mike McGlinchey Jr. | April 24, 2023 | Resigned | Neil Linhart | William Jewell offensive coordinator |
| Concord | Dave Walker | May 12, 2023 | Resigned | Brian Ferguson | Concord offensive coordinator and quarterbacks coach |
| Lincoln (PA) | Josh Dean | June 23, 2023 | Accepted administrative position | Frank Turner | Lincoln (PA) assistant head coach and defensive coordinator |