2022 National Bank Open – Women's singles
Simona Halep defeated Beatriz Haddad Maia in the final, 6–3, 2–6, 6–3 to win the women's singles tennis title at the 2022 Canadian Open. Halep's third Canadian Open title marked the first time in her career she won an event on three occasions and also earned her a ninth WTA 1000 title. This was the last WTA tournament Halep won and her last WTA tournament final. Haddad Maia was the first Brazilian to reach beyond the quarterfinals and contest the final at a WTA 1000 tournament.
Camila Giorgi was the defending champion, but lost in the third round to Jessica Pegula in a rematch of last year's semifinal.
This marked the final Canadian Open appearance for three-time champion and former world No. 1 Serena Williams, who lost in the second round to Belinda Bencic.
Seeds
The top eight seeds received a bye into the second round.Seeded players
The following are the seeded players. Seedings are based on WTA rankings as of August 1, 2022. Rank and points before are as of August 8, 2022.The event is not mandatory on the women's side and points from the 2021 tournament are included in the table below only if they counted towards the player's ranking as of August 8, 2022. For other players, the points defending column shows the lower of points from her second-highest non-mandatory WTA 1000 tournament or her 16th best result.
Points defending will be replaced at the end of the tournament by the player's points from the 2022 tournament, her 17th best result, or points from her second-highest non-mandatory WTA 1000 event.
| Seed | Rank | Player | Points before | Points defending | Points won | Points after | Status | |||
| 1 | 1 |  Withdrawn playersThe following players would have been seeded, but withdrew before the tournament began.
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