2022 BNP Paribas Open – Men's singles
Taylor Fritz defeated Rafael Nadal in the final, 6–3, 7–6 to win the men's singles title at the [2022 BNP Paribas Open|2022 Indian Wells Masters|Indian Wells Masters]. It was his first Masters 1000 title and second career title overall. Fritz was the first American to win the title since Andre Agassi in 2001, and ended Nadal's 20-match winning streak, dating back to the 2022 Melbourne Open.
Cameron Norrie was the defending champion, but lost in the quarterfinals to Carlos Alcaraz, who became the youngest Indian Wells semifinalist since Agassi in 1988.
This was the first ATP Tour tournament since the international governing bodies of tennis allowed players from Russia and Belarus to continue to participate in tennis events on Tour and at the majors, but not under the name or flag of Russia or Belarus until further notice, due to the 2022 Russian invasion of Ukraine.
Daniil Medvedev and Novak Djokovic were in contention for the [List of Association of Tennis Professionals|ATP number 1 ranked singles tennis players|world No. 1 singles ranking]. Despite his withdrawal from the tournament, Djokovic reclaimed the ranking after Medvedev lost to Gaël Monfils in the third round.
With his third-round win, Nadal became the first player to win 400 Masters matches.
Seeds
All seeds received a bye into the second round.Draw
Finals
Seeded players
The following are the seeded players, based on ATP rankings as of March 7, 2022. Rank and points before are as of March 7, 2022.As a result of pandemic-related adjustments to the ranking system and changes to the ATP Tour calendar in 2021, ranking points after the tournament will be calculated as follows:
- Points from tournaments held during the weeks of March 8 and March 15, 2021 will be dropped at the end of the tournament and replaced by points from the 2022 Indian Wells tournament.
- Players who are not defending points from the tournaments listed above will have their 19th best result replaced by their points from the 2022 tournament.
- Points from the 2021 tournament will not drop until October 17, 2022 and are accordingly not reflected in this table.
- The other half of the remaining points from the 2019 tournament will be dropped on March 21, 2022, around three years after the end of the 2019 tournament.
| Seed | Rank | Player | Points before | Points dropped † | Points won | Points after | Status | ||||||||
| 1 | 1 | Daniil Medvedev | 8,615 | 250 | 45 | 8,410 | Third round lost to  Withdrawn playersThe following player would have been seeded, but withdrew before the tournament began.
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