2022 AFC Champions League knockout stage
The 2022 AFC Champions League knockout stage was played from 18 August 2022 to 6 May 2023. A total of 16 teams competed in the knockout stage to decide the champions of the 2022 AFC Champions League.
Qualified teams
The group winners and three best runners-up in the group stage from each region advanced to the round of 16, with both West Region and East Region having eight qualified teams.| Region | Group | Winners | Runners-up |
| West Region | A | Al-Hilal | Al-Rayyan |
| West Region | B | Al Shabab | — |
| West Region | C | Foolad | Shabab Al-Ahli |
| West Region | D | Al-Duhail | — |
| West Region | E | Al-Faisaly | Nasaf Qarshi |
| East Region | F | Daegu FC | Urawa Red Diamonds |
| East Region | G | BG Pathum United | — |
| East Region | H | Yokohama F. Marinos | Jeonbuk Hyundai Motors |
| East Region | I | Johor Darul Ta'zim | — |
| East Region | J | Vissel Kobe | Kitchee |
Format
In the knockout stage, the 16 teams played a single-elimination tournament, with the teams split into the two regions until the final. All ties were played as a single-leg match, except for the final, which was played over two legs. Extra time and penalty shoot-out were used to decide the winners if necessary.
Schedule
The schedule of each round was as follows.| Round | West Region | East Region |
| Round of 16 | 19–20 February 2023 | 18–19 August 2022 |
| Quarter-finals | 23 February 2023 | 22 August 2022 |
| Semi-finals | 26 February 2023 | 25 August 2022 |
| Round | First leg | Second leg |
| Final | 29 April 2023 | 6 May 2023 |
Bracket
Round of 16
Combination tables
;West Region
| Qualified | 1A vs | 1B vs | 1C vs | 1D vs | 1E vs |
| 2A/2B/2C | 1B* | 1A | 2A | 2B | 2C |
| 2A/2B/2D | 1D | 2D | 2A | 1A* | 2B |
| 2A/2B/2E | 1E | 2E | 2A | 2B | 1A* |
| 2A/2C/2D | 1C* | 2D | 1A | 2A | 2C |
| 2A/2C/2E | 2C | 2E | 1E* | 2A | 1C |
| 2A/2D/2E | 2D | 2E | 2A | 1E* | 1D |
| 2B/2C/2D | 2D | 1C* | 1B | 2B | 2C |
| 2B/2C/2E | 2C | 1E | 2E | 2B | 1B* |
| 2B/2D/2E | 2D | 1D* | 2E | 1B | 2B |
| 2C/2D/2E | 2D | 2E | 1D* | 1C | 2C |
;East Region
| Qualified | 1F vs | 1G vs | 1H vs | 1I vs | 1J vs |
| 2F/2G/2H | 1G* | 1F | 2F | 2G | 2H |
| 2F/2G/2I | 1I | 2I | 2F | 1F* | 2G |
| 2F/2G/2J | 1J | 2J | 2F | 2G | 1F* |
| 2F/2H/2I | 1H* | 2I | 1F | 2F | 2H |
| 2F/2H/2J | 2H | 2J | 1J* | 2F | 1H |
| 2F/2I/2J | 2I | 2J | 2F | 1J* | 1I |
| 2G/2H/2I | 2I | 1H* | 1G | 2G | 2H |
| 2G/2H/2J | 2H | 1J | 2J | 2G | 1G* |
| 2G/2I/2J | 2I | 1I* | 2J | 1G | 2G |
| 2H/2I/2J | 2I | 2J | 1I* | 1H | 2H |
Summary
The round of 16 was played over one leg, with the matchups determined by the combination tables based on which group runners-up qualified.
West Region
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East Region
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Quarter-finals
Summary
The quarter-finals were played over one leg.
West Region
----East Region
----Semi-finals
Summary
The semi-finals were played over one leg.
Final
The final was played over two legs.
Urawa Red Diamonds won 2–1 on aggregate.