2021 Karlsruhe Open
The 2021 Karlsruhe Open was a professional tennis tournament played on outdoor clay courts. It was the 2nd edition of the tournament and part of the 2021 WTA 125K series, offering a total of $115,000 in prize money. It took place in Karlsruhe, Germany between 7 and 12 September 2021. The tournament did not take place in 2020 due to the COVID-19 pandemic.
Champions
Singles
Mayar Sherif def. Martina Trevisan, 6–3, 6–2Doubles
Irina Bara / Ekaterine Gorgodze def. Katarzyna Piter / Mayar Sherif, 6–3, 2–6,Singles main draw entrants
Seeds
1 Rankings as of 30 August 2021.Other entrants
The following players received a wildcard into the singles main draw:The following players qualified into the singles main draw:
Withdrawals
;Before the tournament- Ana Bogdan → replaced by Maddison Inglis
- Elisabetta Cocciaretto → replaced by Jaqueline Cristian
- Varvara Gracheva → replaced by Paula Ormaechea
- Polona Hercog → replaced by Ekaterine Gorgodze
- Kristína Kučová → replaced by Rebecca Šramková
- Varvara Lepchenko → replaced by Grace Min
- Jasmine Paolini → replaced by Lucia Bronzetti
- Nuria Párrizas Díaz → replaced by Katarina Zavatska
- Kristýna Plíšková → replaced by Tamara Korpatsch
- Arantxa Rus → replaced by Anastasia Gasanova
- Elena-Gabriela Ruse → replaced by Dalma Gálfi
- Viktoriya Tomova → replaced by Cristina Bucșa
- Zhang Shuai → replaced by Katarzyna Kawa
Doubles entrants
Seeds
1 Rankings as of 30 August 2021.Other entrants
The following pair received a wildcard into the doubles main draw:- Nastasja Schunk / Alexandra Vecic