2021–22 Gamma Ethniki
The 2021–22 Gamma Ethniki was the 39th season since the official establishment of the championship in 1983, and the first after the reestablishment as the 3rd tier of the Greek Football.
It started on 23 October 2021. After the finish of the seven groups, the champion of each group qualified for a playoff round, to determine which four teams will be promoted to 2022–23 Super League 2.
81 teams are divided into seven groups according to geographical criteria.
Group 1
Teams
Standings
Group 2
Teams
Standings
Group 3
Teams
Standings
Group 4
Teams
| Team | Location | Last season |
| Ethnikos Skoulikado | Skoulikado | |
| A.O. Aias Gastouni | Gastouni | |
| Diagoras Vrachnaiika | Vrachnaiika | |
| Tilikratis | Lefkada | |
| Anagennisi Arta | Arta | |
| Panegialios | Aigio | |
| Nafpaktiakos Asteras | Nafpaktos | |
| A.O. Diavolitsi | Diavolitsi | |
| PAS Acheron Kanallaki | Kanallaki | |
| Panachaiki | Patras | |
| Amvrakikos Loutro | Loutro | |
| PAO Varda | Varda | |
| Panagriniakos | Agrinio |