2018 Knoxville Challenger

The 2018 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the fifteenth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Knoxville, United States between 5 and 11 November 2018.

Singles main-draw entrants

¹ Rankings are as of October 29, 2018.

The following players received wildcards into the singles main draw:

The following player received entry into the singles main draw as a special exempt:

The following players received entry into the singles main draw as alternates:

The following players received entry from the qualifying draw:

Reilly Opelka def. Bjorn Fratangelo 7–5, 4–6, 7–6.

Toshihide Matsui / Frederik Nielsen def. Hunter Reese / Tennys Sandgren 7–6, 7–5.