2-Aminothiophenol


2-Aminothiophenol is an organosulfur compound with the formula C6H4. It is a colorless oily solid, although impure samples can be deeply colored. It is soluble in organic solvents and in basic water. 2-Aminothiophenol is a precursor to benzothiazoles, some of which are bioactive or are commercial dyes. Isomers of aminothiophenols include 3-aminothiophenol and 4-aminothiophenol.
2-Aminothiophenol can prepared in two steps, starting with the reaction of aniline with carbon disulfide followed by hydrolysis of the resulting mercaptobenzothiazole. It can also obtained by zinc reduction of 2-nitrobenzenesulfonyl chloride.

Applications

2-Aminothiophenol is used in the synthesis of the following list of agents:
  1. DDD-016
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  1. Thioproperazine
  2. Cinanserin
  3. .