DDD-016

DDD-016 is a novel pentacyclic compound initially designed and synthesized as a potential atypical antipsychotic, with its receptor binding affinities screened across a broad panel of over 80 central nervous system and other receptors. As part of a series of investigational compounds—which also includes DDD-024, DDD-025, and DDD-029 stands out for its proposed anti-psychotic activity, believed to be mediated through dual serotonin 5-HT_2A and dopamine D2 receptor antagonism.

Synthesis

A Goldberg reaction between 2-aminothiophenol and 2-bromobenzyl bromide gives 5,11-Dihydrodibenzothiazepine, . Nitrosylation with nitrous acid gives. This is then reduced to the amino group. Condensation with 1-Methyl-4-piperidone gives. Fischer indole synthesis completes the synthesis.