2,5-Dimethoxy-p-cymene

2,5-Dimethoxy-p-cymene, or thymohydroquinone dimethyl ether, is a phytochemical found in the essential oils of plants within the family Asteraceae. These essential oils, which contain the compound as a major component of the oil, have antifungal, antibacterial, and insecticidal properties.

Natural occurrence

2,5-Dimethoxy-p-cymene occurs in a variety of different plants' essential oils. Examples include:Ayapana triplinervis Apium leptophyllum Cyathocline purpurea Arnica montana Laggera crispata Blumea perrottetiana Eupatorium capillifolium Sphaeranthus indicus Limbarda crithmoides

''Bubonium imbricatum''

Chemical synthesis

2,5-Dimethoxy-p-cymene can be synthesized from carvacrol by aromatic halogenation followed by nucleophilic substitution with sodium methoxide and Williamson ether synthesis using methyl iodide.