2,3-Dichlorophenylpiperazine


2,3-Dichlorophenylpiperazine is a chemical compound from the phenylpiperazine family. It is both a precursor in the synthesis of aripiprazole and one of its metabolites. It is unclear whether 2,3-DCPP is pharmacologically active as a serotonin receptor agonist similar to its close analogue 3-chlorophenylpiperazine, though it has been shown to act as a partial agonist of the dopamine D2 and D3 receptors.

Legality

2,3-DCPP has been made illegal in Japan and Hungary after having been identified in seized designer drug samples.

List of derivatives

  1. Aripiprazole
  2. Cariprazine
  3. BAK 2-66
  4. Brilaroxazine
  5. FAUC-365
  6. CJB-090 2xHCl
  7. NGB 2849
  8. NGB 2904 Fb: HCl:
  9. 2xHCl:
  10. PG648
  13. So-called
  14. So-called
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Positional Isomer

The positional isomer 3,4-dichlorophenylpiperazine is also known, and acts as both a serotonin releaser via the serotonin transporter, and a β1-adrenergic receptor blocker, though with relatively low affinity at both targets.

Triple Substituted

The 3,4,5-Trichlorophenylpiperazine is also a highly regarded arrangement & has been awarded the Beecham patent of. Such 3,4,5-Trisubstituted aromatic entities is already known from clenbuterol. Leading to i.e. 1--4-piperazine.