Thorpe reaction


The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines. The reaction was discovered by Jocelyn [Field Thorpe].
Image:Thorpe [Reaction Scheme.png|center|500px|The Thorpe reaction]

Thorpe–Ziegler reaction

The Thorpe–Ziegler reaction, or Ziegler method, is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.