ZFXZinc finger X-chromosomal protein is a protein that in mammals is encoded by the ZFX gene of the X chromosome.FunctionThis gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krüppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain, a nuclear [localization sequence] and a DNA [binding domain] consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for stem [cell self-renewal|self-renewal] of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. Clinical significanceThe gene is associated with X-linked neurodevelopmental disorder.