Yale School of Medicine
The Yale School of Medicine is the medical school of Yale University, a private Ivy League research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. It is the sixth-oldest medical school in the United States.
The school’s faculty clinical practice is Yale Medicine. Yale School of Medicine has a strong affiliation with its primary teaching hospital, Yale New Haven Hospital and the Yale New Haven Health System. The school is home to the Harvey Cushing/John Hay Whitney Medical Library, which is one of the country’s largest modern medical libraries and is known for its historical collections.
For the class of 2028, the school received 5,669 applications to fill 104 seats in the MD Program. This puts the acceptance rate at about 1.6%. The median GPA for the class was 3.94, and the median MCAT score was 521.
Education
Yale School of Medicine educates future leaders in medicine and biomedical science. Since 1839, medical students have written a thesis based on original research, reflecting that the scientific process of investigation, observation, interpretation of data, and critical evaluation of literature are fundamental to the practice of medicine.Many medical students take a tuition-free fifth year to pursue additional study, conducting in-depth research or exploring clinical electives and sub-internships. A significant number are awarded fifth-year research fellowships and earn the Master of Health Science degree.
Each year, approximately 20 students enroll in the school’s MD-PhD Program, one of the original Medical Scientist Training Programs established and funded by the National Institutes of Health (NIH). Graduate students in the combined program in the Biomedical and Biological Sciences earn a PhD degree through the Faculty of Arts and Sciences. YSM residents, fellows, and faculty, as well as individuals from other institutions, can earn a two-year Master of Health Science degree. The Yale School of Medicine also offers joint degree programs with other professional schools, including Public Health, Law, Management, Engineering & Applied Science, and Divinity.
YSM’s campus-based Physician Associate (PA) Program, one of the oldest PA programs in the country, trains students to become compassionate, high-quality, patient-centered PAs.
Yale System
The school employs the "Yale System" established by YSM Dean Milton Winternitz in the 1920s, wherein first- and second-year students are not graded or ranked among their classmates. In addition, course examinations are anonymous and are intended only for students' self-evaluation. Student performance is thus based on seminar participation, qualifying examinations, clinical clerkship evaluations, and the United States Medical Licensing Examination. Prior to graduation, students are required to submit a thesis based on original research.Rankings
For 2024, U.S. News & World Report ranked Yale School of Medicine as a Tier 1 medical school in Best Medical Schools: Research, as a Tier 3 school in Best Medical Schools: Primary Care, tied for No.33 in Most Diverse Medical Schools, No.90 in Most Graduates Practicing in Health Professional Shortage Areas, No.169 in Most Graduates Practicing in Primary Care, and tied at No.161 in Most Graduates Practicing in Rural Areas. The school ranked third for NIH research funding in 2024 as reported by the Blue Ridge Institute for Medical Research.History
In 18th-century United States, credentials were not needed to practice medicine. Prior to the founding of the medical school, Yale graduates would train through an apprenticeship to become physicians. Yale President Ezra Stiles conceived the idea of training physicians at Yale and ultimately, his successor Timothy Dwight IV helped found the medical school. The school was chartered in 1810 and opened in New Haven in 1813. Nathan Smith and Benjamin Silliman were the first faculty members. Silliman was a professor of chemistry and taught at both Yale College and the medical school. The other two founding faculty were Jonathan Knight, anatomy, physiology and surgery, and Eli Ives, pediatrics.One of Yale's earliest medical graduates was Dr. Asaph Leavitt Bissell of Hanover, New Hampshire, who graduated in 1815, a member of the school's second graduating class. Following his graduation, Dr. Bissell moved to Suffield, Connecticut, a tobacco-farming community where his parents had lived and where he practiced as a country physician for the rest of his life. The saddlebags that Dr. Bissell carried in his practice, packed with paper packets and glass bottles, are today in the school's Medical Historical Library.
In 1916, a little more than a century after its founding, Yale School of Medicine admitted its first female students. At the time, this stood in marked contrast to the ethos of other institutions such as Harvard, which considered it “unladylike” for women to attend medical school at the time. The three women admitted to the Class of 1916 were exceptional—unlike their male counterparts, who needed only two years of college education, they were required to hold a college degree, and a quota further restricted the number of women who were admitted.
Throughout its history, Yale School of Medicine faculty have been credited with seminal scientific discoveries. Pediatrician Martha May Eliot, MD, who was recruited to Yale by Edwards A. Park, MD, chair of the medical school’s first Department of Pediatrics, are together credited with developing a cure for rickets in 1925.
Early in 1942, Louis S. Goodman, MD, and Alfred Gilman, PhD, assistant professors in Yale’s new Department of Pharmacology, began to study nitrogen mustard, an agent that was derived from a lethal gas used in the trenches of World War I. Building on research that had languished for years, the two young scientists found in a derivative of mustard gas the first effective chemotherapy for cancer.
In 1998, Charles Janeway, MD, Yale Cancer Center immunologist, established and proved his theory of innate immunity.
In the 1960s, Louis Gluck, MD, a member of the Department of Pediatrics faculty, created the first neonatal intensive care unit (NICU). In the late 1970s, William Tamborlane, MD, and the late Robert Sherwin, MD, transformed the treatment of type 1 diabetes by developing the insulin pump.
Research led by Yale School of Medicine endocrinologist Kevan Herold, MD, resulted in the Food and Drug Administration's approval in 2022 of teplizumab (Tzield®), a medication that can delay the onset of type 1 diabetes—marking the first treatment to change the course of this autoimmune disease since the discovery of insulin in 1922.
In the field of psychiatry, following pioneering research led by Yale School of Medicine psychiatrist John Krystal, MD, and his colleagues Dennis Charney, MD, and Ronald Duman, PhD, the Food and Drug Administration approved in 2019 a nasal spray called esketamine, derived from ketamine, for treatment-resistant depression.
The original building later became Sheffield Hall, part of the Sheffield Scientific School. In 1860, the school moved to Medical Hall on York Street, near Chapel. In 1925, the school moved to its current campus, neighboring the hospital. This campus includes the Sterling Hall of Medicine, Boyer Center for Molecular Medicine, Anlyan Center and the Amistad Building ).
On March 28, 2022, Jamie Petrone-Codrington, a former administrator pled guilty to fraud and tax charges for the theft of over $40 million of computer and electronic software. Jamie Petrone-Codrington illegally bought and sold hardware purchased for the School of Medicine, starting in 2013. According to the court records, Petrone-Codrington was turned in by an anonymous tip after being seen loading computer equipment into her private vehicle, and after ordering high volumes of equipment.
Clinical Affiliations
An affiliation agreement between the medical school and Grace-New Haven Community Hospital in 1965 created Yale New Haven Hospital (YNHH), which expanded in 1993 with the opening of the Children’s Hospital, and again in 2000 with the acquisition of the Psychiatric Hospital.In 1999, an affiliation agreement was established between the medical school and Yale New Haven Health System. The two institutions collaborate to provide clinical care, undergraduate and graduate medical education, and to facilitate clinical research.
In 2009, the 14-story Smilow Cancer Hospital opened, and in 2012 YNHH acquired the Hospital of Saint Raphael, adding 533 beds and making it one of the largest hospitals in the United States.
The medical center has grown over the years to include the institutions listed below.
The affiliated VA Connecticut Healthcare System, located in West Haven, maintains clinical, research, and education programs in conjunction with many medical school departments. The Department of Psychiatry collaborates with the Connecticut Mental Health Center to provide recovery-oriented mental health services for thousands of people in the Greater New Haven area each year.
Deans
Before 1845, there was no dean. Nathan Smith, followed by Jonathan Knight, provided leadership in the early years. Thereafter, physicians of various specialities have served as dean of the medical school:- Charles Hooker : professor of anatomy and physiology
- : physician and professor of materia, medica, and therapeutics; later professor of the theory and practice of medicine
- : physician and chemist
- : psychiatrist and scientist
- : pathologist
- Stanhope Bayne-Jones, MD : bacteriologist
- Francis Gilman Blake, MD : immunologist
- Cyril Norman Hugh Long, MD : physician and biochemist
- : pediatrician
- Frederick Carl Redlich, MD : psychiatrist
- Lewis Thomas, MD : immunologist and author
- : renal physiologist
- Leon Rosenberg, MD : geneticist
- : gastroenterologist
- : endocrinologist
- David Aaron Kessler, MD : pediatrician, lawyer, and former commissioner of the Food and Drug Administration
- : neurosurgeon
- : nephrologist
- Nancy J. Brown, MD : internist and clinical pharmacologist
Notable faculty
The faculty includes 31 National Academy of Sciences members, 50 National Academy of Medicine members, and nine Howard Hughes Medical Institute investigators/professors. Yale School of Medicine faculty have also received various international awards for their scientific discoveries, impactful research, and professional achievements. The Nobel Prize in Physiology or Medicine has been awarded to seven current or former faculty members, and the Nobel Prize in Chemistry to two faculty members.Current
- Amy Arnsten, PhD, Albert E. Kent Professor of Neuroscience and professor of psychology
- Pietro De Camilli, MD, John Klingenstein Professor of Neuroscience and professor of cell biology
- Vincent DeVita Jr., MD, Amy and Joseph Perella Professor of Medicine and professor of epidemiology
- , Waldemar Von Zedtwitz Professor of Medicine, professor of epidemiology and of microbial pathogenesis, and section chief for infectious disease in YSM’s Department of Internal Medicine
- Richard Flavell, PhD, Sterling Professor of Immunobiology
- Jorge Galàn, DVM, PhD, Lucille P. Markey Professor of Microbial Pathogenesis and professor of cell biology
- Valentina Greco, PhD, Carolyn Slayman Professor of Geneitcs
- Tamas Horvath, DVM, PhD, Jean and David W. Wallace Professor of Comparative Medicine and professor of neuroscience and of obstetrics, gynecology & reproductive sciences
- Arthur L Horwich, MD, professor emeritus of genetics
- Akiko Iwasaki, PhD, Sterling Professor of Immunobiology and professor of dermatology and of molecular, cellular & developmental biology, and of epidemiology
- , Robert L. McNeil Jr. Professor of Translational Research, chair and professor of psychiatry, and professor of neuroscience and of psychology
- Haifan Lin, PhD, Eugene Higgins Professor of Cell Biology and professor of genetics, of obstetrics, gynecology & reproductive sciences, and of dermatology, director of Yale Stem Cell Center
- Ruslan Medzhitov, PhD, Sterling Professor of Immunobiology
- Marcella Nunez-Smith, MD, MHS, CNH Long Professor of Internal Medicine and professor of epidemiology and of public health, associate dean for health equity research
- Lucila Ohno-Machado, MD, MBA, PhD, Waldemar von Zedtwitz Professor of Medicine and of Biomedical Informatics & Data Science, deputy dean for biomedical informatics, chair of biomedical informatics & data science
- Marina Picciotto, PhD, Charles B.G. Murphy Professor of Psychiatry and professor in the Yale Child Study Center, of neuroscience, and of pharmacology
- Pasko Rakic, MD, PhD, Dorys McConnell Duberg Professor of Neuroscience and professor of neurology
- James Rothman, PhD, Sterling Professor of Cell Biology and professor of chemistry
- David G. Schatz, PhD, Waldemar Von Zedtwitz Professor of Immunobiology and Professor of Molecular Biophysics and Biochemistry, chair, Immunobiology
- Joseph Schlessinger, PhD, Willian H. Prusoff Professor of Pharmacology
- Nenad Sestan, MD, PhD, Harvey and Kate Cushing Professor of Neuroscience and professor of comparative medicine, of genetics, and of psychiatry
- Joan A. Steitz, PhD, Sterling Professor of Molecular Biophysics & Biochemistry
- Stephen Strittmatter, MD, PhD, Vincent Coates Professor of Neurology and professor of neuroscience
- Mary Tinetti, MD; Gladys Philips Crofoot Professor of Medicine
- Emily Wang, MD, professor of medicine and of public health
Past
- Sidney Altman, PhD : Sterling Professor of Molecular, Cellular & Developmental Biology, discovered the catalytic properties of RNA, Nobel Prize in Chemistry, 1989
- Paul B Beeson, MD : chair and professor of internal medicine and expert in infection
- C. Lee Buxton, MD : obstetrician, birth control advocate, and appellant in Griswold v. Connecticut
- Russell Henry Chittenden, PhD, : physiological chemist, pioneer of digestion and nutrition
- James William Colbert, Jr., MD : immunologist, assistant dean of postgraduate education
- Harvey Cushing, MD : neurosurgeon, pioneer of brain surgery, identified Cushing's syndrome
- Jennifer Doudna, PhD ; former Henry Ford II Professor of Molecular Biophysics and Biochemistry, Nobel Prize in Chemistry, 2020
- John F. Enders, PhD : vaccine pioneer, including development of the measles vaccine
- Marilyn Farquhar, PhD : cell biologist, first female Sterling Professor at Yale
- Stephen Fleck, MD : psychiatrist, coauthor of Schizophrenia and the Family
- John Farquhar Fulton, MD, DSc : Sterling Professor of Physiology, neurophysiology of primates
- Arnold Gesell, MD : psychologist and pediatrician, developed the Yale Child Study Center
- Alfred Gilman Sr., PhD : pharmacologist, chemotherapy pioneer and co-author of The Pharmacological Basis of Therapeutics
- Patricia Goldman-Rakic, PhD : neurobiologist, pioneer of studies on the frontal lobe and the cellular basis of working memory
- Paul Greengard, PhD ; former professor of pharmacology and psychiatry, Nobel Prize in Physiology or Medicine, 2000
- Harry S.N. Greene, MD : professor of pathology
- Beatrix Hamburg, MD : adolescent psychiatrist and the first African-American female to attend Yale School of Medicine
- Orvan Hess, MD : developed the fetal heart monitor and early use of penicillin
- Dorothy Horstmann, MD : epidemiologist, virologist, pioneer in the study of polio, first female to receive an endowed chair at Yale
- James D. Jamieson, MD, PhD : cell biologist, established the function of the Golgi apparatus alongside George Palade, MD
- Brian Kobilka, MD : physiologist, YSM alumnus, recipient of the Nobel Prize in Chemistry, 2012
- Theodore Lidz, MD : Sterling Professor of Psychiatry, researcher of schizophrenia
- Lafayette Mendel, PhD : biochemist, discoverer of vitamin A, vitamin B, and essential amino acids
- Sherwin B. Nuland, MD : clinical professor of surgery, winner of the National Book Award for How We Die: Reflections on Life's Final Chapter
- George Emil Palade, MD : a founding father of modern cell biology, Sterling Professor of Cell Biology, Nobel Prize in Physiology or Medicine, 1974
- William Prusoff, PhD : discovered idoxuridine, the first antiviral agent approved by the Food and Drug Administration, and discovered the anti-HIV effect of stavudine(D4T)
- Juan Rosai, MD : professor of pathology and director of the Department of Anatomic Pathology, author of surgical pathology textbook, discovered Rosai-Dorfman disease and desmoplastic small round cell tumor
- Leon E. Rosenberg, MD : dean and inaugural chair of the Department of Genetics
- Richard Selzer, MD : surgeon and author
- : endocrinologist and diabetes researcher, led the Yale Center for Clinical Investigation
- Nathan Smith, MD : professor of physics, surgery and obstetrics, founder of Dartmouth Medical School and co-founder of the University of Vermont College of Medicine
- Albert J. Solnit, MD : psychoanalyst, child rights advocate, and Sterling Professor of Psychiatry
- Thomas A. Steitz, PhD : Sterling Professor of Biophysics and Biochemistry, 2009 Nobel Prize in Chemistry, discovered the atomic structure of the ribosome
- Edward Tatum, PhD : former professor of microbiology, Nobel Prize in Physiology or Medicine, 1958
- Max Theiler, MD : former professor of epidemiology and microbiology, Nobel Prize in Physiology or Medicine, 1951
- Richard W. Tsien, PhD : former assistant professor in the Department of Physiology, characterized calcium channel types
- John Vane, DPhil : former assistant professor the Department of Pharmacology, Nobel Prize in Physiology or Medicine, 1982
- Frans Wackers, MD, PhD : nuclear cardiologist, former director of the Cardiovascular Nuclear Imaging and Stress Laboratories
- : pediatric cardiologist who provided pre- and post-operative care for the infant who received the first “blue baby” operation in 1944
- : dean, established the Yale System of Medical Education