Y box binding protein 1

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene. YBX1 is an RNA binding protein that stabilises messenger RNAs modified with N6-methyladenosine.

Clinical significance

YBX1 is a potential drug target in cancer therapy. YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy. Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

DNA repair

The mitochondria of human cells possess a repair pathway for DNA base pair mismatches that is distinct from the DNA mismatch repair pathway of the nucleus. This mitochondrial pathway includes participation of Y box binding protein 1, that likely acts in the mismatch binding and recognition steps of mismatch repair.

Interactions

Y box binding protein 1 has been shown to interact with: