William Worthington
William Worthington may refer to:
- William Worthington (actor), American silent film actor and director
- William Worthington (priest), Anglican priest and theological writer
- William Barton Worthington, British civil engineer
- William Grafton Delaney Worthington, American lawyer, judge, and politician
- William H. Worthington, American farmer, lawyer, and military officer
- William Jackson Worthington, American politician
- William Chesley Worthington, editor of The Providence Journal and editor of the ''Brown Alumni Monthly''