William Wickham
William Wickham may refer to:
- William Wickham (bishop), English bishop
- William Wickham (civil servant), British civil servant and politician; spymaster during the French Revolution
- William Wickham (cricketer), English cricketer
- William Wickham (Conservative politician), Member of Parliament for Petersfield, 1892–1897; grandson of William Wickham
- William Wickham (New York politician), American farmer, businessman, member of the New York State Assembly
- William Wickham, social reformer and campaigner for the Parliamentary [Reform Act 1832]
- William H. Wickham, New York mayor