William Vaughan
William Vaughan may refer to:
- William Vaughan , English landowner, farmer and philanthropist
- Sir William Vaughan , Welsh writer and colonial investor
- Sir William Vaughan , English royalist commander in the First English Civil War
- William Gwyn Vaughan, Welsh politician
- William Vaughan , Member of Parliament for and Lord Lieutenant of Merioneth
- William Vaughan , English West India merchant and author
- William Vaughan , Roman Catholic Bishop of Plymouth
- William Wirt Vaughan, member of the United States House of Representatives
- William Wyamar Vaughan, British educationalist
- William Vaughan , English footballer
- William E. Vaughan, American columnist and author
- William Vaughan , British art historian
- William Edward Vaughan, Irish historian
- W. Harry Vaughan, founder of the Georgia Tech Research Institute