William Pratt
William or Billy Pratt may refer to:
- William Abbott Pratt, American photographer
- William B. Pratt, American physician and politician
- William Pratt, English politician
- William Henry Pratt, real name of actor Boris Karloff
- William Pratt, ancestor of the Pratt-Romney family
- William Pratt , English rugby league footballer of the 1950s for Leeds, and Halifax
- William K. Pratt, American educator, businessman, and author
- William V. Pratt, admiral in the United States Navy
- William Pratt , English cricketer
- William Dymock Pratt, English architect
- William Pratt , Canadian businessman
- Billy Pratt , English football winger for Small Heath from 1889 to 1892
- Billy Pratt , English football full-back for Small Heath from 1894 to 1902
- Spike, a character from television series ''Buffy the Vampire Slayer''