William Nye
William Nye may refer to:
- Bill Nye, American science educator, comedian, television host and mechanical engineer
- Will Nye, American television actor in Murder, She Wrote
- William Foster Nye, businessman who founded Nye Lubricants in 1844
- William B. Nye, former member of the 107th and 108th Ohio General Assembly
- William M. Nye, member of the Wisconsin State Assembly
- William Nye (official), Secretary-General of the Archbishops' Council
- William Nigh, American filmmaker, sometimes credited as "William Nye"