William Lowndes

• William Lowndes (1652–1724), British politician and Secretary to the Treasury
• William Lowndes (1752-1828), British lawyer, parliamentary draftsman and Chief Commissioner of the Board of Taxes
• William Lowndes (congressman), U.S. Congressman from South Carolina
• William Selby Lowndes, British Member of Parliament
• William Thomas Lowndes, English bibliographer, whose principal work was ''The Bibliographer’s Manual of English Literature''