William Locke

• William Locke of Norbury 18th-century English patron of the arts, see Joseph Wilton
• William Henry Locke, chaplain and writer during the American Civil War
• William Locke , officer in the Australian Army
• William John Locke, English novelist, born in British Guyana of English parents
• William Locke, owner of the Philadelphia Phillies in 1913 on List of Philadelphia Phillies owners and executives