William Little
William Little or Billy Little may refer to:
- William Brian Little, founding partner of Forstmann Little & Company, a private equity firm
- William Carruthers Little, Ontario farmer and political figure
- William H. Little, founder of the Little Motor Car Company 1911–1913
- William John Little, English surgeon who identified cerebral palsy in children
- William Little , Australian fiction writer and poet
- William Little , politician in Pittsburgh
- William Grady Little, former manager of the Boston Red Sox and Los Angeles Dodgers
- William Little , member of the Queensland Legislative Assembly, Australia
- William McCarty Little, United States Navy officer
- William Nelson Little, court martialed in 1915 on charges of negligence during his inspection of the submarine USS K-2
- Billy Little, Scottish footballer
- Billy Little, English rugby league footballer who played in the 1930s and 1940s
- Billy Little , rugby league footballer who played in the 1930s for England, and Barrow