William Humphreys
William Humphreys may refer to:
- William Y. Humphreys, U.S. Congressman from Mississippi
- William [Jackson Humphreys], American physicist and meteorologist
- William Humphreys Jackson, U.S. Congressman from Maryland
- William Humfrey, also written William Humphreys, Elizabethan goldsmith
- William [Benbow Humphreys], South African politician
- William Humphreys (footballer), English footballer
- Billy Humphreys, English footballer