William Humphrey
William Humphrey may refer to:
- William Humphrey (engraver), English printseller
- William Humphrey (cricketer), English cricketer
- William Humphrey (writer), American novelist
- William Humphrey (Northern Ireland politician), Northern Irish unionist
- William E. Humphrey, American politician
- William F. Humphrey, Canadian politician in the Legislative Assembly of New Brunswick
- William J. Humphrey, film director
- Willie Humphrey, jazz clarinetist
- William Humfrey, mining promoter, Assay Master at the Royal Mint